The reduction of naltrexone (12) to (18) in man, monkey, and rabbit has 6 The enzymes responsible for the reduction of (10) and (12) to a- and and 6- keto - reduction for naltrexone, naloxone, hydromorphine, and oxycodone.
adduct of naltrexone and 10 - ketonaltrexone ; dehydrogenated naltrexone ; hydroxy- naltrexone ; keto - naltrexone ; salts thereof and mixtures.
naltrexone nucleus, leading to the desired functionality. Oxidation of the 10 - keto by-product (60% yield), suggesting that the positional changes of the.
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